What symptom is associated with elevated urine metanephrine levels in a young female patient?

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Elevated urine metanephrine levels are indicative of catecholamine-secreting tumors, such as pheochromocytomas, which are more common in the adrenal glands and can lead to episodes of catecholamine release. One of the classic symptoms associated with this condition is headache. The release of catecholamines, such as adrenaline and noradrenaline, can cause significant increases in blood pressure and sympathetic nervous system activation, which often results in severe headaches.

In contrast, symtpoms such as rash, fever, and dizziness are not typically correlated with elevated metanephrine levels. A rash could suggest an allergic reaction or dermatological issue, fever often points to infection or inflammation, and dizziness can result from a variety of causes including dehydration or inner ear problems, but none are specifically linked to the presence of excess catecholamines. Thus, headache stands out as the symptom most closely associated with elevated urine metanephrine levels.

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