In a patient with allergic-mediated pruritis, which statement is true?

In cases of allergic-mediated pruritus, the use of oral antihistamines is well-established as a primary therapeutic approach. These medications function by blocking histamine receptors, which are responsible for the symptoms associated with allergic reactions, including itching. By providing relief from these symptoms, oral antihistamines can significantly improve patient comfort.

Oral doses are particularly beneficial because they offer systemic effects that can address widespread itching, compared to topical treatments which may be limited in their area of effectiveness. Starting therapy with oral antihistamines allows for a broader and more effective management of allergic pruritus.

The other statements lack support based on clinical practice guidelines and the nature of treating allergic reactions. For instance, H2 antagonists primarily target gastric acid and do not address histamine-mediated pruritus. Similarly, while topical antihistamines might provide localized relief, their effectiveness is not as robust as that of oral antihistamines. Lastly, potassium permanganate baths are not commonly recommended for treating allergic pruritus and are typically used for other dermatological conditions.